![]() ![]() Understanding how these adaptations evolved through changes to biochemical and cellular processes will reveal fundamental insights into areas ranging from anatomy and metabolism to behaviour and ecology. There are an estimated 10,000 reptile species worldwide, found on every continent except Antarctica, with a diversity of lifestyles and morphologies 1 corresponding to a broad range of anatomic and physiological adaptations. The evolution of form and function in non-avian reptiles contains numerous examples of innovation and diversity. The Komodo dragon genome is an important resource for understanding the biology of monitor lizards and reptiles worldwide. Together, these evolutionary signatures of adaptation reveal the genetic underpinnings of the unique Komodo dragon sensory and cardiovascular systems, and suggest that selective pressure altered haemostasis genes to help Komodo dragons evade the anticoagulant effects of their own saliva. We also show species-specific expansions of a chemoreceptor gene family related to pheromone and kairomone sensing in V. komodoensis with those of related species, we find evidence of positive selection in pathways related to energy metabolism, cardiovascular homoeostasis, and haemostasis. ![]() komodoensis using a hybrid approach of long-range sequencing and single-molecule optical mapping. Here, we sequence the genome of the Komodo dragon Varanus komodoensis, the largest extant monitor lizard, and generate a high-resolution de novo chromosome-assigned genome assembly for V. Monitor lizards are unique among ectothermic reptiles in that they have high aerobic capacity and distinctive cardiovascular physiology resembling that of endothermic mammals. Nature Ecology & Evolution volume 3, pages 1241–1252 ( 2019) Cite this article That is why all of our trips are flightless in destination, fully carbon offset - and we have ambitious plans to be net zero in the very near future.Genome of the Komodo dragon reveals adaptations in the cardiovascular and chemosensory systems of monitor lizards We are committed to go as far as possible in curating our trips with care for the planet. We know that many of you worry about the environmental impact of travel and are looking for ways of expanding horizons in ways that do minimal harm - and may even bring benefits. Our Private Trips are fully tailored itineraries, curated by our Travel Experts specifically for you, your friends or your family. Our Rail Trips are our most planet-friendly itineraries that invite you to take the scenic route, relax whilst getting under the skin of a destination. Culture Trips are deeply immersive 5 to 16 days itineraries, that combine authentic local experiences, exciting activities and 4-5* accommodation to look forward to at the end of each day. Our Trips are suitable for both solo travelers, couples and friends who want to explore the world together. That is why we have intensively curated a collection of premium small-group trips as an invitation to meet and connect with new, like-minded people for once-in-a-lifetime experiences in three categories: Culture Trips, Rail Trips and Private Trips. Increasingly we believe the world needs more meaningful, real-life connections between curious travellers keen to explore the world in a more responsible way. We are proud that, for more than a decade, millions like you have trusted our award-winning recommendations by people who deeply understand what makes certain places and communities so special. Culture Trip launched in 2011 with a simple yet passionate mission: to inspire people to go beyond their boundaries and experience what makes a place, its people and its culture special and meaningful - and this is still in our DNA today. Since you are here, we would like to share our vision for the future of travel - and the direction Culture Trip is moving in. ![]()
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